Duodenal Mucosal Biopsies
نویسندگان
چکیده
Synthesis of prostaglandins (PGE2, PGI2 and PGF2,:) and thromboxane A2 was investigated in short term incubates of duodenal mucosa biopsies. Mucosa close to the ulcer site synthesised significantly less PGF2a (p<0.001) and PGI2 (p<0-002) measured as its stable metabolite 6-oxo-PGF1, than healthy mucosa from non-ulcer patients. In paired biopsies taken from the ulcer site and opposite the ulcer in the same patient PGF20, and PGI2 syntheses were both significantly and similarly depressed when compared with normal mucosa. Synthesis of PGE2 and TxA2 (as its stable metabolite TxB2) was not different in any tissue. There is a defect in the ability of the human duodenal mucosa in duodenal ulcer disease to synthesise PGF20, and PGI2; the defect is not limited to the ulcer site.
منابع مشابه
Importance of duodenal bulb biopsies in children for diagnosis of celiac disease in clinical practice
BACKGROUND The patchy nature of villous lesion in celiac disease is increasingly being recognized. Current guidelines recommend four endoscopic duodenal mucosal biopsies from the second or more distal part of the duodenum to confirm the diagnosis of celiac disease. The purpose of the study was to investigate the usefulness of duodenal bulb mucosal biopsies in confirming the diagnosis of celiac ...
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